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2004-2009   華中科技大學(xué)同濟(jì)醫(yī)學(xué)院神經(jīng)病學(xué)博士

2009-2012   濱州醫(yī)學(xué)院附屬醫(yī)院神經(jīng)內(nèi)科,   講師，主治醫(yī)師

2012-2014   美國(guó)德克薩斯大學(xué)圣安東尼奧健康科學(xué)中心, 博士后

2014-           濱州醫(yī)學(xué)院代謝與神經(jīng)精神疾病研究所

研究方向：神經(jīng)退行性疾病機(jī)理研究，抗抑郁機(jī)理研究

代表論著：

1.D Zhang1, X Wang1,2, B Wang1,3, J C Garza1, X Fang1, J Wang1, P E Scherer4, R Brenner3, W Zhang1 and X-Y Lu1,2,5 Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors Molecular Psychiatry advance online publication 3 May 2016; doi: 10.1038/mp.2016.58 

2.Carrier N, Wang X (co-first author), Sun L, Lu XY * (2015) Sex-specific and estrous cycle-dependent antidepressant-like effects and hippocampal Akt signaling of leptin. Endocrinology, in press.

3. Wang X, Zhang D, Lu XY * (2015) Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin. Mol Psychiatry. 20(4):509 -519. 

4.Zhang M, Wang X, Jiang F, Wang W, Vincent I, Bu B. Mitotic epitopes are incorporated into age-dependent neurofibrillary tangles in Niemann-Pick disease type C. Brain Pathol. 2010, 20(2):367-77.(Co-First author).

5.Wang X ,Tang R, Xue Z, Jiang F, Zhang M, Bu B. Lentivector-mediated RNAi efficiently downregulates expression of murine TNF-alpha gene in vitro and in vivo. J Huazhong Univ Sci Technolog Med Sci. 2009, 29(1):112-7. 

6.Xue Z, Wang X, Liu F, Hu S, Zhu S, Zhang S, Bu B. Intracranial hypertension syndrome in Systemic Lupus Erythematosus: clinical analysis and review of the literature. J Huazhong Uni Sci Techol, 2009, 29(1):107-111.(co-first author). 

7.Feng JIANG, Xuezhen WANG, Zheng XUE, Suming ZHANG, Siyu FANG, Min ZHANG. Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene in vitro. Front. Med. 2009,3(3):287-91. 

8.Zhang M, Hallows JL, Wang X, Bu B, Wang W, Vincent I. Mitogen-activated protein kinase activity may not be necessary for the neuropathology  of Niemann-Pick type C mice. J Neurochem. 2008, 107(3):81

承擔(dān)課題：

1.國(guó)家自然科學(xué)基金項(xiàng)目：Grb10對(duì)AD相關(guān)的認(rèn)知功能障礙和神經(jīng)病理變化的影響及其機(jī)制研究。立項(xiàng)時(shí)間：2015-2017年，負(fù)責(zé)人：王雪貞。