1997-2001 沈陽(yáng)藥科大學(xué)，藥學(xué)學(xué)士
2001-2005 沈陽(yáng)藥科大學(xué), 藥理學(xué)博士
2005-2007 香港中文大學(xué), 研究助理
2012-present 濱州醫(yī)學(xué)院代謝與神經(jīng)精神疾病研究所, 副教授，副所長(zhǎng)
研究方向：
瘦素受體信號(hào)傳導(dǎo)系統(tǒng)在情緒行為調(diào)控中的作用：應(yīng)用瘦素受體酪氨酸磷酸化位點(diǎn)敲除小鼠模型，采用行為學(xué)、分子生物學(xué)、電生理等實(shí)驗(yàn)方法探討瘦素作用機(jī)制。
代表論著：
1.Guo M , Li C , Lei Y , Xu S , Zhao D , Lu XY* (2016). Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors.Mol Psychiatry. 2016 Dec 13. doi: 10.1038/mp.2016.225. [Epub ahead of print]
2. Liu J, Guo M, Lu XY* (2015) Leptin/LepRb in the ventral tegmental area mediates anxiety-related behaviors. Int J Neuropsychopharmacol. 2015 in press.
3.Guo M, Lu XY. Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates.Translational Psychiatry (2014) 4, e486;doi:10.1038/tp.2014.126
4. Guo M, Huang TY, Garza JC, Chua SC, Lu XY. Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours. Int J Neuropsychopharmacol. 2013 May; 16(4):857-67.
5. Liu J, Guo M, Zhang D, Cheng SY, Liu M, Ding J, Scherer PE, Liu F, Lu XY. Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12248-53.
6. Guo M, Lu Y, Garza JC, Li Y, Chua SC, Zhang W, Lu B, Lu XY. Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. Transl Psychiatry. 2012; 2:e83.
7. Garza JC, Guo M, Zhang W, Lu XY. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling. Mol Psychiatry. 2012 Jul; 17(8):790-808.
8. Zhang D, Guo M(共同第一作者）, Zhang W, Lu XY. Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3β (GSK-3β)/β-catenin signaling cascade. J Biol Chem. 2011 Dec 30; 286(52):44913-20.
9. Yu T, Guo M, Garza J, Rendon S, Sun XL, Zhang W, Lu XY. Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction. Int J Neuropsychopharmacol. 2011 Apr;14(3):303-17.
10. Garza JC, Guo M, Zhang W, Lu XY. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem.2008 Jun 27; 283(26):18238-47.
11. Guo M, Xu NJ, Li YT, Yang JY, Wu CF, Pei G. Morphine modulates glutamate release in the hippocampal CA1 area in mice.Neurosci Lett. 2005 Jun 10-17; 381(1-2):12-5.
12. Hao Y, Yang JY, Guo M, Wu CF, Wu MF. Morphine decreases extracellular levels of glutamate in the anterior cingulate cortex: an in vivo microdialysis study in freely moving rats. Brain Res. 2005 Apr 8;1040 (1-2):191-6.
13. Guo M, Wu CF, Wang JH, Pei G. Effects of ginsenosides on the actions of morphine. Zhongguo Zhong Yao Za Zhi. 2004 Apr; 29(4):299-301. Review. Chinese.
14. Guo M, Wang JH, Yang JY, Zhu D, Xu NJ, Pei G, Wu CF, Li X. Roles of ginsenosides on morphine-induced hyperactivity and rewarding effect in mice. Planta Med. 2004 Jul; 70(7):688-90.
15. Guo M, Wu CF, Liu W, Yang JY, Chen D. Sex difference in psychological behavior changes induced by long-term social isolation in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan; 28(1):115-21.
承擔(dān)課題：
1.國(guó)家自然科學(xué)基金項(xiàng)目: VTA瘦素敏感神經(jīng)元投射到杏仁核和終紋床核的神經(jīng)通路對(duì)焦慮行為和HPA軸的調(diào)節(jié)作用及機(jī)制研究。立項(xiàng)時(shí)間2018-2021年，負(fù)責(zé)人：郭明。
2.國(guó)家自然科學(xué)基金項(xiàng)目: 瘦素受體酪氨酸磷酸化位點(diǎn)在情緒行為調(diào)控中的作用和信號(hào)傳導(dǎo)機(jī)制研究（81301164）。立項(xiàng)時(shí)間：2014-2016年，負(fù)責(zé)人：郭明。
3.煙臺(tái)市科技發(fā)展計(jì)劃項(xiàng)目：瘦素對(duì)海馬5-羥色胺神經(jīng)遞質(zhì)傳遞的影響。立項(xiàng)時(shí)間：2013-2017年，負(fù)責(zé)人：郭明。
4.教育部留學(xué)回國(guó)人員科研啟動(dòng)基金項(xiàng)目：瘦素與氟西汀的抗抑郁作用及對(duì)海馬谷氨酸手提系統(tǒng)影響的比較。立項(xiàng)時(shí)間：2013年，負(fù)責(zé)人：郭明。
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